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KMID : 1237720180510040292
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Anatomy & Cell Biology
2018 Volume.51 No. 4 p.292 ~ p.298
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Amelioration of experimental autoimmune encephalomyelitis by Ishige okamurae
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Ahn Mee-Jung
Kim Jeong-Tae
Yang Won-Jun
Choi Yu-Na
Ekanayake Poornima
Ko Hyun-Ju
Jee Young-Heun
Shin Tae-Kyun
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Abstract
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Experimental autoimmune encephalomyelitis (EAE) is a T-cell-mediated autoimmune central nervous system disease characterized by inflammation with oxidative stress. The aim of this study was to evaluate an anti-inflammatory effect of Ishige okamurae on EAE-induced paralysis in rats. An ethanolic extract of I. okamurae significantly delayed the first onset and reduced the duration and severity of hind-limb paralysis. The neuropathological and immunohistochemical findings in the spinal cord were in agreement with these clinical results. T-cell proliferation assay revealed that the ethyl-acetate fraction of I. okamurae suppressed the proliferation of myelin basic protein reactive T cells from EAE affected rats. Flow cytometric analysis showed TCRαβ+ T cells was significantly reduced in the spleen of EAE rats with I. okamurae treatment with concurrent decrease of inflammatory mediators including tumor necrosis factor-α and cyclooxygenase-2. Collectively, it is postulated that I. okamurae ameliorates EAE paralysis with suppression of T-cell proliferation as well as decrease of pro-inflammatory mediators as far as rat EAE is concerned.
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KEYWORD
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Experimental autoimmune encephalomyelitis, Inflammation, Ishige okamurae, Spinal cord
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